Gonadotropins

Gonadotropins are peptide hormones that regulate ovarian function and are essential for normal growth, sexual development and reproduction. Human gonadotropins include follicle stimulating hormone (FSH) and luteinizing hormone (LH) which are made in the pituitary, and chorionic gonadotropin (hCG) which is made by the placenta. All three gonadotropins are heterodimeric proteins that consist of two peptide chains, with the alpha chain similar in all three, whereas the beta chain is unique and determines the fine receptor specificity and function of each hormone.

HMG

Human Menopausal Gonadotropin combination of FSH and LH in a 1:1 ratio that is extracted from urine obtained from postmenopausal women, widely used for Controlled Ovarian stimulation to stimulate the recruitment and development of multiple eggs during an ovulation induction cycle in women undergoing Assisted Reproductive Technology (ART) like IUI, IVF and ICSI.

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HMG

Human Menopausal Gonadotropin combination of FSH and LH in a 1:1 ratio that is extracted from urine obtained from postmenopausal women, widely used for Controlled Ovarian stimulation to stimulate the recruitment and development of multiple eggs during an ovulation induction cycle in women undergoing Assisted Reproductive Technology (ART) like IUI, IVF and ICSI.

Therapeutic Uses of HMG:

  • Used for Ovulation Induction/Controlled Ovarian stimulation in infertile women as part of
  • Assisted Reproductive
  • Technology (IUI / In-Vitro Fertilization (IVF)/ ICSI treatment)
  • Used for Spermatogenesis - Hypogonadotrophic hypogonadism in men

Formulations/Strengths:

  • Lyophilized (Single dose vials): 75 IU & 150 IU
  • Liquid Form Multi-dose Vials: 600 IU & 1200 IU

Available in:

  • Lyophilized form (to be reconstituted) and
  • The liquid form (Ready to use) Single & Multi-dose Vials;

Method of Administration:

  • Intramuscular or subcutaneous use by registered practitioners only

DISCLAIMER: †GYNOGEN is a trademark of Sanzyme Private Limited excluding India. This disclosure does not intend to market and commercialize GYNOGEN in India but for export purposes only.

FSH

Follicle Stimulating Hormone used for Controlled Ovarian stimulation to stimulate the recruitment and development of multiple eggs during an ovulation induction cycle in women undergoing Assisted Reproductive Technology (ART) like IUI, IVF and ICSI. FSH may be used alone or in combination with human menopausal gonadotropin (hMG) to induce superovulation.

Therapeutic Uses of FSH:

  • Used for Ovulation Induction/Controlled Ovarian stimulation in infertile women as part of
  • Assisted Reproductive Technology (IUI / In-Vitro Fertilization (IVF)/ ICSI treatment)

Formulations/Strengths:

  • Lyophilized (Single dose vials): 75 IU & 150 IU
  • Liquid Form Multi-dose Vials: 600 IU & 1200 IU

Available in:

  • Lyophilized form (to be reconstituted) and
  • The liquid form (Ready to use) Single & Multi-dose Vials;

Method of Administration:

  • Intramuscular or subcutaneous use by registered practitioners only

DISCLAIMER: †ENDOGEN is a trademark of Sanzyme Private Limited excluding India. This disclosure does not intend to market and commercialize ENDOGEN in India but for export purposes only.

HCG

Human Chorionic Gonadotropin is a pregnancy supporting hormone extracted from the urine of pregnant women and is widely used as an Ovulation Trigger that helps with the final maturation of the eggs and triggers the ovaries to release the mature eggs (ovulation) in women undergoing Assisted Reproductive Technology (ART) like IUI, IVF and ICSI. It also stimulates the corpus luteum to secrete progesterone to prepare the lining of the uterus for implantation of the fertilized egg.

HCG

Human Chorionic Gonadotropin is a pregnancy supporting hormone extracted from the urine of pregnant women and is widely used as an Ovulation Trigger that helps with the final maturation of the eggs and triggers the ovaries to release the mature eggs (ovulation) in women undergoing Assisted Reproductive Technology (ART) like IUI, IVF and ICSI. It also stimulates the corpus luteum to secrete progesterone to prepare the lining of the uterus for implantation of the fertilized egg.

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Therapeutic Uses in the Female:

  • Ovulation induction in subfertility due to anovulation or impaired follicle-ripening.
  • Preparation of follicles for puncture in controlled ovarian hyperstimulation programs (for medically assisted reproductive techniques).
  • Luteal phase support.

Therapeutic Uses in the Male:

  • Hypogonadotropic hypogonadism (also cases of idiopathic dysspermias have shown a positive response to gonadotropins).
  • Delayed puberty associated with insufficient gonadotropic pituitary function.
  • Cryptorchidism, not due to anatomical obstruction.
  • Preoperative preparation of ectopic testes

Available Formulations/Strengths

  • 500 IU / 1000 IU / 1500 IU / 2000 IU / 5000 IU / 7500 IU / 10000 IU

Available in

  • Lyophilized or powder form (to be reconstituted)
  • Liquid form (Ready to use)

Method of Administration

  • Intramuscular or subcutaneous use by registered practitioners.

DISCLAIMER: †PUBERGEN is a trademark of Sanzyme Private Limited excluding India. This disclosure does not intend to market and commercialize PUBERGEN in India but for export purposes only.

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