Infertility is a growing concern worldwide, and assisted reproductive technologies (ART) such as in vitro fertilization (IVF) have given hope to millions of couples. Among the many factors that determine IVF success, gonadotropins—key reproductive hormones—play a vital role in stimulating and supporting ovulation, egg maturation, and implantation.
Understanding Gonadotropins
Gonadotropins are hormones secreted by the pituitary gland that regulate reproductive function. The three most important gonadotropins used in fertility treatments are:
- FSH (Follicle Stimulating Hormone) – Stimulates the growth and development of ovarian follicles.
- HMG (Human Menopausal Gonadotropin) – Contains both FSH and LH (Luteinizing Hormone) activity, promoting follicular growth and ovulation.
- HCG (Human Chorionic Gonadotropin) – Mimics the natural LH surge, triggering ovulation and preparing the body for implantation.
Role of FSH in IVF
In IVF cycles, recombinant or urinary FSH is administered to stimulate multiple follicles in the ovaries. This allows the retrieval of several mature eggs, increasing the chances of successful fertilization. The dose and duration of FSH depend on individual ovarian response, age, and hormonal profile.
Importance of HMG in Fertility Treatments
Human Menopausal Gonadotropin (HMG) is derived from the urine of postmenopausal women and contains both FSH and LH activity. It is often used when the body requires additional LH support. Urinary Gonadotropins in IVF protocols are preferred in many clinics for their proven effectiveness and affordability compared to recombinant options.
HCG: The Ovulation Trigger
Once the follicles mature, HCG injections are given to induce the final stage of egg maturation and ovulation. The timing of the HCG injection in India and elsewhere is crucial—typically 34–36 hours before egg retrieval—to ensure optimal results.
Why Quality Gonadotropins Matter
The success of any IVF treatment heavily depends on the purity, potency, and consistency of gonadotropin preparations. Reliable sourcing from trusted Gonadotropin Manufacturers in India – SANZYME ensures that fertility clinics receive high-quality products that meet international regulatory standards. Sanzyme of India is one of the leading pharmaceutical companies producing HMG, FSH, and HCG formulations that are exported globally.
Conclusion
The combined use of HMG, FSH, and HCG forms the foundation of most controlled ovarian stimulation protocols in IVF. Understanding their individual and synergistic roles helps clinicians tailor treatment plans for the best outcomes. As technology advances, newer and purer gonadotropin formulations continue to improve the safety, efficacy, and accessibility of fertility treatments.
Keywords: Gonadotropin Manufacturers in India, Urinary Gonadotropins in IVF, HCG Injection India, HMG in IVF, FSH stimulation, fertility treatment hormones.
Last modified: October 30, 2025
